MIT Unit Affiliation:
Lab Affiliation(s):
Ortiz Laboratory
Post Doc Sponsor / Advisor:
Prof. Christine Ortiz
Areas of Expertise:
  • Controlled drug delivery system
  • Micro- and nanopatterned shape-memory polymer surfaces
  • Nanoimprint lithography for surface patterning
Date PhD Completed:
February, 2012
Expected End Date of Post Doctoral Position:
October 15, 2016

Wei Li Lee

  • Post Doctoral

MIT Unit Affiliation: 

  • Materials Science and Engineering

Lab Affiliation(s): 

Ortiz Laboratory

Post Doc Sponsor / Advisor: 

Prof. Christine Ortiz

Date PhD Completed: 

Feb, 2012

Top 3 Areas of Expertise: 

Controlled drug delivery system
Micro- and nanopatterned shape-memory polymer surfaces
Nanoimprint lithography for surface patterning

Expected End Date of Post Doctoral Position: 

October 15, 2016

CV: 

Thesis Title: 

Controlled Drug Release from Multi-Phase Polymeric Particles

Thesis Abstract: 

The study of the fabrication of multi-phase particles (i.e. double-layered ternary-phase microparticles, triple-layered and quadruple-layered microparticles) and their drug release profiles is reported in this thesis. The overall objective is to investigate the use of multi-phase/multi-layered microparticles with different morphologies and layer configurations as a means to control and fine-tune the drug release profiles. The results obtained show conclusive evidence that different microparticle configurations (i.e. polymer distribution and dimensions) can be achieved through the manipulation of process parameters in a one-step solvent evaporation technique. A starting polymer solution prepared below the cloud point, low stirring speed and an increased oil-to-water ratio facilitated the polymers to configure themselves towards thermodynamic equilibrium configurations. A considerably high polymer precipitation rate was needed to kinetically trap the triple-layered structure when the polymer solution was prepared above cloud point. Layer thickness and configuration were altered by changing the polymer mass ratios. Drugs can be localized within specific layers of the microparticles. A correlation of these process parameters to the final particle morphology was thus established. The ternary-phase and triple-layered microparticles were observed to provide unique and better controlled drug release as compared to single-layered and double-layered microparticles. This was due to their distinctive structural attributes and degradation behaviors of the multiple-polymer system. Drug release profiles can be further altered by changing the physicochemical properties of each polymer phase. A modeled relationship between the physicochemical processes and drug release was established for triple-layered microparticles of different layer thicknesses and particle sizes. It is concluded that the multi-phase/multi-layered microparticles can be used to better control drug release profiles and kinetics.

 

Top 5 Awards and honors (name of award, date received): 

SUTD-MIT Postdoctoral Fellowship, Oct 2014-Oct 2016
Best Poster Presentation Award at Small Sciences Symposium: Frontiers in Nanomedicine, Singapore, 2012
Top 20 (out of 800) Selected Papers from the 24th European Conference on Biomaterials, Ireland, 2011
Dean’s List, 2008
Accelerated Bachelor’s Programme, 2004-2007

5 Recent Papers: 

W.L. Lee, H.Y. Low, Geometry- and length scale-dependent deformation and recovery on micro- and nanopatterned shape memory polymer surfaces, Scientific Reports 6 (2016) 23686.

W.L. Lee,  W.M. Guo, V.H.B. Ho, A. Saha, H.C. Chong, N.S. Tan, E.Y. Tan, S.C.J. Loo, Delivery of doxorubicin and paclitaxel from double-layered microparticles: The effects of layer thickness and dual-drug vs. single-drug loading, Acta Biomaterialia 27 (2015) 53-65.

W.L. Lee,  W.M. Guo, V.H.B. Ho, A. Saha, H.C. Chong, N.S. Tan, E. Widjaja, E.Y. Tan, S.C.J. Loo, Inhibition of 3-D tumor spheroids by timed-released hydrophilic and hydrophobic drugs from multilayered polymeric microparticles, Small 10 (2014) 3986-3996.

W.L. Lee, C. Loei, E. Widjaja, S.C.J. Loo, Altering the drug release profiles of double-layered ternary-phase microparticles, Journal of Controlled Release 151 (2011) 229-238.

W.L. Lee, E. Widjaja, S.C.J. Loo, One-step fabrication of triple-layered polymeric microparticles with layer localization of drugs as a novel drug-delivery system, Small 6 (2010) 1003-1011.

Contact Information: