Department:
Lab Affiliation(s):
Koch Institute for Integrative Cancer Research
Advisor:
Paula T. Hammond
Areas of Expertise:
  • nanomaterials
  • in vivo application (husbandry, experimentation)
  • drug delivery
Expected date of graduation:
June 5, 2014

Stephen Morton

  • PhD

Department: 

  • Chemical Engineering

Lab Affiliation(s): 

Koch Institute for Integrative Cancer Research

Advisor: 

Paula T. Hammond

Top 3 Areas of Expertise: 

nanomaterials
in vivo application (husbandry, experimentation)
drug delivery

Expected date of graduation: 

June 5, 2014

CV: 

Thesis Title: 

Multi-functional, multi-drug therapeutic platforms for disease management

Thesis Abstract: 

The complexity of growth, survival, and death signaling pathways in cancer continues to motivate extensive investigations using systems biology approaches to inform treatments against cancer. With this progress, development of delivery systems that are safe, yet capable of sophisticated levels of control over the delivery, timing, or sequence of release, in order to therapeutically re-wire these signaling pathways, are essential to translate these drug combinations to the clinic. My work has focused on the development of material systems, employing both self-assembled and top-down manufacturing strategies, towards targeted, controlled delivery of therapeutics for more efficacious treatment of cancer, with broad application to a range of diseased states. 

5 Recent Papers: 

S.W. Morton*, M.J. Lee*, Z.J. Deng, E.C. Dreaden, E. Siouve, K.E. Shopsowitz, N.J. Shah, M.B. Yaffe, and P.T. Hammond. (2014), “A Nanoparticle-Based Combination Chemotherapy Delivery System for Enhanced Tumor Killing by Dynamic Rewiring of Signaling Pathways,” Science Signaling, 7, ra44. [http://stke.sciencemag.org/content/7/325/ra44.editor-summary]

S.W. Morton*, N.J. Shah*, M.A. Quadir, Z.J. Deng, Z. Poon, P.T. Hammond. (2014), “Osteotropic delivery via LbL nanoparticles,” Advanced Healthcare Materials, 3(6), 867-75. [http://onlinelibrary.wiley.com/doi/10.1002/adhm.201300465/abstract]

S.W. Morton*, X. Zhao*, M.A. Quadir, P.T. Hammond. (2014), “FRET-enabled biological characterization of polymeric micelles,” Biomaterials, 34(21), 5328-5335. [http://www.sciencedirect.com/science/article/pii/S0142961214000295]

S.W. Morton, K.P. Herlihy, K.E. Shopsowitz, Z.J. Deng, K.S. Chu, C.J. Bowerman, J.M. DeSimone, P.T. Hammond. (2013), “Scalable Manufacture of Built-to-Order Nanomedicine: Spray-assisted Layer-by-Layer Functionalization on PRINT® Nanoparticles,” Advanced Materials, 25(34): 4707-13. [http://onlinelibrary.wiley.com/doi/10.1002/adma.201302025/abstract]

S.W. Morton, Z. Poon, P.T. Hammond. (2013), "The Architecture and Biological Performance of LbL Nanoparticles," Biomaterials, 34(21): 5328-5335. [http://www.sciencedirect.com/science/article/pii/S0142961213003815]

Contact Information:
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(704) 641-5224